名称：抗KLHL22抗体(anti-KLHL22 antibody)

　　货号：FNab04620

　　适应种属：人源，大鼠，小鼠

　　规格：100ug(微克)

　　状态：液体

　　纯化方法：免疫亲和纯化

　　纯度：经sds-page分析，纯度大于95

　　宿主：兔

　　亚型：igg

　　存储：用添加了0.02叠氮化钠和50甘油的pbs溶解，ph值7.3，可在-20℃下保存12个月（避免反复冻融）

　　免疫原：kelch-like 22(Drosophila)

　　分子量：72 kDa

　　验证应用：ELISA, WB

　　建议稀释比例：WB: 1:500-1:2000

　　克隆性：多克隆

　　uniprot id：Q53GT1

　　背景介绍：Substrate-specific adapter of a BCR(BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint(SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation。

　　mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab04620(KLHL22 antibody) at dilution of 1:3000。